Michael Ashton Selected Research

Falciparum Malaria (Plasmodium falciparum Malaria)

1/2018	Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis.
7/2017	MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy.
11/2012	A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan.
1/2012	The evaluation of CYP2B6 inhibition by artemisinin antimalarials in recombinant enzymes and human liver microsomes.
5/2011	Orally formulated artemisinin in healthy fasting Vietnamese male subjects: a randomized, four-sequence, open-label, pharmacokinetic crossover study.
11/2010	Population pharmacokinetics and pharmacodynamics of artemether and lumefantrine during combination treatment in children with uncomplicated falciparum malaria in Tanzania.
8/2008	The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese volunteers.
10/2007	Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria.
8/2002	Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria.
4/2002	Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage regimens.

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Michael Ashton Research Topics

Disease

10	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2018 - 04/2002
7	Malaria 01/2018 - 04/2002
6	Tuberculosis (Tuberculoses) 10/2022 - 11/2013
4	African Trypanosomiasis (Nagana) 01/2022 - 01/2011
4	Infections 01/2020 - 02/2016
4	Acquired Immunodeficiency Syndrome (AIDS) 11/2013 - 04/2008
2	Mental Disorders (Mental Disorder) 10/2023 - 12/2022
2	Neglected Diseases 01/2022 - 01/2021
1	Trichomonas Infections 07/2022
1	Anaphylaxis (Anaphylactic Shock) 07/2022
1	Immediate Hypersensitivity 07/2022
1	Pruritus (Itching) 07/2022
1	Urticaria (Hives) 07/2022
1	Parasitic Diseases (Parasitic Disease) 09/2020
1	Breast Neoplasms (Breast Cancer) 12/2014
1	Drug-Related Side Effects and Adverse Reactions 02/2014
1	Chronic Renal Insufficiency 05/2004

Drug/Important Bio-Agent (IBA)

6	artemisinin (artemisinine)IBA 02/2016 - 04/2002
5	efavirenz (Sustiva)FDA Link 02/2014 - 04/2008
4	Eflornithine (Ornidyl)FDA Link 01/2022 - 01/2011
4	artenimol (dihydroartemisinin)IBA 01/2018 - 08/2008
4	piperaquineIBA 02/2016 - 08/2008
3	Rifampin (Rifampicin)FDA LinkGeneric 10/2022 - 01/2019
3	Isoniazid (Ftivazide)FDA LinkGeneric 10/2022 - 01/2019
3	Artemether FDA Link 01/2018 - 11/2010
3	Lumefantrine FDA Link 07/2017 - 11/2010
2	Hallucinogens (Psychedelics)IBA 10/2023 - 12/2022
2	N,N-Dimethyltryptamine (Dimethyltryptamine)IBA 10/2023 - 12/2022
2	Pyrazinamide FDA LinkGeneric 01/2021 - 01/2019
2	Ethambutol (Myambutol)FDA LinkGeneric 01/2020 - 01/2019
2	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 02/2014 - 04/2008
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 02/2014 - 08/2011
1	4-nitroimidazoleIBA 07/2022
1	Immunoglobulin E (IgE)IBA 07/2022
1	Metronidazole (Metric)FDA LinkGeneric 07/2022
1	Tinidazole FDA Link 07/2022
1	pyrazinoic acidIBA 01/2021
1	5-hydroxypyrazinamideIBA 01/2021
1	PolyaminesIBA 01/2021
1	Cytochrome P-450 CYP1A2 (CYP1A2)IBA 01/2020
1	Isonicotinic Acids (Isonicotinic Acid)IBA 01/2020
1	Antitubercular AgentsIBA 01/2019
1	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 01/2018
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 07/2017
1	ArtesunateIBA 12/2014
1	EnzymesIBA 02/2014
1	Urea (Carbamide)FDA LinkGeneric 08/2011
1	Adenosine Triphosphate (ATP)IBA 08/2011
1	Alanine Transaminase (SGPT)IBA 08/2011
1	CreatinineIBA 08/2011
1	Cytochrome P-450 CYP3AIBA 08/2011
1	Amodiaquine (Camoquin)FDA Link 10/2007
1	desethylamodiaquineIBA 10/2007
1	candesartan cilexetil (Amias)FDA Link 05/2004
1	Angiotensin Receptor AntagonistsIBA 05/2004
1	Antiparasitic Agents (Antiparasitics)IBA 08/2002
1	Mefloquine (Lariam)FDA LinkGeneric 08/2002
1	Antimalarials (Antimalarial Agents)IBA 08/2002

Therapy/Procedure

5	Therapeutics 01/2022 - 05/2004
2	Oral Administration 12/2014 - 08/2011